Air Pollution, Climate Conditions and Risk of Psychotic Hospitalization in U.S. Residents
Year: 2022
Type: conference-abstract
Abstract: Objective: The physical environmental risk factors for psychotic disorders are poorly understood. This study aimed to examine the associations between residential exposure to ambient air pollution, key climate measures and risk of psychotic hospitalization in the U.S. general population and uncover potential disparities by demographic and community factors. Methods: Using data from Health Cost and Utilization Project (HCUP) State Inpatient Databases (SIDs), we applied zero-inflated negative binomial regression to obtain the relative risks of psychotic hospitalization associated with increases in residential exposure to ambient air pollution (fine particulate matter, PM2.5; nitrogen dioxide, NO2), temperature and cumulative precipitation. All the exposures were aggregated to ZIP code level, and later merged with admission data by ZIP code of residence and calendar year. The analysis covered all-age residents in eight U.S. states over the period of 2002 – 2016. We additionally investigated modification by age, sex, area-level poverty, percent of blacks and Hispanics via stratified models. Results: Over the study period and among the covered areas, we identified 1,211,100 psychotic admissions. For each interquartile (IQR) increase in exposure to PM2.5 and NO2, we observed a relative risk (RR) of 1.11 (95% CI = 1.09, 1.13) and 1.27 (95% CI = 1.24, 1.31), respectively. For each 1 ºC increase of temperature, the RR was 1.03 (95% CI = 1.03, 1.04). We did not find significant associations with precipitation in the total population. Older age residents (>= 30 yrs.) were more sensitive to PM2.5 and ambient temperature. Population living in economically disadvantaged areas were more affected by air pollution. Area percent of Hispanics level modified the associations in different directions depending on the exposure. Conclusions: The study findings suggest that living in areas with higher levels of air pollutants and ambient temperature could contribute to additional risk of psychotic hospitalization in a U.S. general population.
Source: ISEE Conference Abstracts
Institutions: Harvard University, Boston University, Emory University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4317178312