Exposures to environmental phenols and asthma risk
Year: 2022
Type: conference-abstract
Abstract: Background: Prenatal exposure to bisphenol (BP) A has been associated with asthma. While the mechanisms underlying these associations are poorly understood, altered endocrine disruption, upregulated allergic immune response, altered response to oxidative stress, and mitochondrial dysfunction have been implicated in the adverse respiratory effects. As a result of these associations, the use of BPA has been banned in certain materials (i.e. baby bottles), although exposure remains prevalent. In many cases, BPA has been replaced with structurally similar chemicals, including BPF and BPS, despite the uncertain safety of these compounds. Methods: We assessed whether prenatal exposure to BPA and analogues BPF and BPS among mothers participating in the Environmental Influences on Child Health Outcomes (ECHO) study was associated with respiratory and allergic outcomes among their offspring. Exposure measures (adjusted for urinary dilution using the Boeniger method), outcomes, and covariates (including sex, race, child BMI, mode of delivery, maternal smoking status, income, education, parental asthma history, sibling and pet ownership) were harmonized across ECHO cohorts, and asthma was assessed in children ages 5-9 years. Multivariable logistic regression was applied to estimate associations between exposure and outcome. Results/Conclusions: In the ECHO consortium, we evaluated 830,645, and 771 mother-child pairs for analysis of associations between BPA, BPF, and BPS, and asthma. Preliminary results did not suggest associations between prenatal BPA, BPF, or BPS with asthma, but child BMI and parental history of asthma showed significant associations with child asthma. Ongoing analyses will examine: 1) the impact of additional harmonized covariates including season, 2) variation across cohorts in the relationship between prenatal phenol exposure and asthma diagnosis, and 3) associations between BPA, BPF, and BPS on additional outcomes such as rhinitis, wheeze phenotypes, asthma phenotypes, and atopic dermatitis.
Source: ISEE Conference Abstracts
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4317178401