Get started
Work

Urinary Zinc and Incident Diabetes: Prospective Evidence from the Strong Heart Study

Year: 2022
Type: conference-abstract
Abstract: Background and aim: Diabetes, a chronic metabolic condition, is a major risk factor for cardiovascular disease. Hyperglycaemia can increase zinc excretion due to its insulin-mimetic function. We aimed to assess the association between urinary zinc and incident diabetes in two populations with a high burden of diabetes from Arizona, Oklahoma, North Dakota and South Dakota. Methods: Baseline urinary zinc was measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in 1,339 adults free of diabetes at baseline (1989-1991) and followed through 1998-1999 in the Strong Heart Study (SHS) and in 1,905 family members of SHS participants free of diabetes at baseline (1998-1999) followed as part of the Strong Heart Family Study (SHFS) through 2006-2009. Results: In the SHS, diabetes incidence was 14.7% (mean follow-up 6.6 years). Median urinary zinc was 0.46 mg/g and 0.50 mg/g for participants without and with diabetes, respectively. After adjustment for sex, site, education, smoking status, and BMI, the hazard ratio (HR) (95%CI) of diabetes comparing IQR percentiles of urinary zinc distribution was 1.21 (1.08, 1.36). In the SHFS, diabetes incidence was 13.5% (mean follow-up 5.6 years). Median urinary zinc was 0.59 and 0.65 for participants without and with diabetes, respectively. The HR(95%CI) in the SHFS was 1.12 (0.96, 1.31). These associations were attenuated in the SHS after adjustment for insulin levels, fasting glucose levels and HOMA-IR score. Excluding participants with prediabetes at baseline, the association of urinary zinc with incident diabetes remained significant in the SHS and suggestive for the SHFS. Conclusions: Baseline urinary zinc concentrations were associated with diabetes incidence even after adjustment for fasting plasma insulin and plasma glucose levels in adult populations with a high burden of diabetes. These results highlight the need for greater understanding of zinc metabolism in diabetes pathology and identify possible treatment approaches for diabetes prevention.
DOI: 10.1289/isee.2022.p-0063
Authors: Marta Galvez-Fernandez, Martha Powers, Maria Grau-Perez, Arce Domingo-Relloso, Nancy Lolacono, Walter Goessler, Ying Zhang, Amanda Fretts, Jason G Umans, Nisa Maruthur, Ana Navas-Acien
Institutions: Columbia University, Northeastern University, University of Graz, University of Oklahoma Health Sciences Center, University of Washington, Georgetown University Medical Center, Johns Hopkins University
Language: English
Field: Nursing
Open Access status: diamond
OpenAlex ID: W4317181610
Cites:
Cited by:
Related to: 10