Prenatal exposure to mixtures of non-persistent endocrine disrupting chemicals and respiratory health in children from the Rhea birth cohort study, Greece
Year: 2022
Type: conference-abstract
Abstract: BACKGROUND AND AIM: Endocrine-disrupting chemicals (EDCs) are present in many consumer products and can affect the development and functions of the immune system. There is growing concern over the role of EDCs, including phthalates, bisphenol A (BPA) and parabens, on early life origins of respiratory diseases, however, results are inconsistent and most studies assessed one chemical at a time. We investigated whether prenatal phthalates, BPA and parabens are associated with childhood wheeze and asthma using a mixtures approach in the RHEA birth cohort in Greece. METHODS: We quantified concentrations of seven phthalate metabolites, six parabens, and BPA in first trimester maternal urine. Information on wheezing and asthma up to 11 years was obtained from parent-completed questionnaires and lung function by spirometry. Multiple regression and quantile g-computation was used to assess the independent and joint associations between the EDCs and respiratory outcomes, respectively. RESULTS: Prenatal exposure to monobenzyl-, mono(2-ethyl-5-hydroxyhexyl)-, and mono(2-ethyl-5-oxohexyl)- phthalates was associated with increased risk for early wheezing (≤4 years). Mono(2-ethyl-5-hydroxyhexyl) and mono-isobutyl phthalates were associated with higher FEV1 and FEV1/FVC ratio at 6 years, respectively. Methyl paraben was associated with increased risk for late wheezing (>4 years) and n-butyl paraben was associated with increased risk for current asthma at 6 years and ever asthma. Moreover, methyl and n-propyl parabens were associated with higher FEV1 at 6 years. We did not find any associations between prenatal BPA and any of the respiratory outcomes. In the mixture analysis, one quartile increase in phthalates was associated with higher FEV1 and in parabens with higher FEV1/FVC ratio at 6 years, respectively. CONCLUSIONS: Our data indicate that prenatal exposures to phthalates, parabens and their mixtures may be associated with child respiratory health. Further research is needed to verify these findings and shed light on the molecular mechanisms. KEYWORDS: prenatal, phthalates, parabens, mixtures
Source: ISEE Conference Abstracts
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4317181622