Per- and polyfluoroalkyl substances in early to mid-pregnancy and gestational diabetes mellitus: A multi-racial/ethnic longitudinal study
Year: 2022
Type: conference-abstract
Abstract: Background and Aim: Per- and polyfluoroalkyl substances (PFAS) as endocrine disruptors have been linked to glucose homeostasis. Data on PFAS and gestational diabetes (GDM) are scarce and inconclusive. We examined prospective associations of PFAS in early to mid-pregnancy with GDM risk. Methods: Within the prospective Pregnancy Environment and Lifestyle Study, we conducted a nested case-control study of 41 GDM cases diagnosed at gestational weeks 24-28 and 87 controls. Fourteen PFAS analytes were measured in serum collected in the first and second trimesters, with cumulative concentrations estimated by area-under-the-curve (AUC). Weighted logistic regression examined seven PFAS with at least 50% of values above the limit of detection in association with GDM risk, adjusting for age, race/ethnicity, pre-pregnancy body mass index, and parity. P-values were corrected using false-discovery-rate (FDR). We examined effect modification by Asian/Pacific Islander (A/PI) or non-A/PI given the higher risk of GDM in A/PI. Results: Per interquartile range (IQR) increase in first-trimester concentrations of perfluorodecanoic acid [PFDA; adjusted odds ratio (95% CI): 1.23 (1.09-1.38)], perfluorononanoic acid [PFNA; 1.40 (1.24-1.58)], and perfluorooctanoic acid [PFOA; 1.15 (1.04-1.27)] were associated with a higher GDM risk; results were similar for the second-trimester and AUC concentrations (all FDR <0.01). Per IQR increase in concentrations of perfluorooctanesulfonic acid [PFOS; 1.41 (1.17,1.71)] and perfluroundecanoic acid [PFUnDA; 1.49 (1.18-1.89)] in the second trimester were associated with a higher GDM risk (both FDR <0.01). These associations were more prominent among A/PI who had higher PFAS concentrations than non-A/PI. Perfluorohexane-1-sulphonic acid (PFHxS) concentrations across different times were inversely associated with GDM risk (aOR ranged 0.46-0.49); however; these associations were positive among A/PI (all FDR <0.001). Conclusions: Early to mid-pregnancy serum concentrations of PFDA, PFOA, PFOS and PFUnDA were positively, whereas PFHxS were inversely associated with GDM risk. Future work examining PFAS in mixture and GDM risk is underway.
Source: ISEE Conference Abstracts
Institutions: Kaiser Permanente, Kaiser Permanente Northern California
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4317181905