Work

Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine

Year: 2023

Type: article

Abstract: Inflammation is a key mechanistic contributor to the progression of cardiovascular disease, from atherosclerosis through ischemic injury and overt heart failure. Recent evidence has identified specific roles of immune cell subpopulations in cardiac pathogenesis that diverges between individual patients. Nuclear imaging approaches facilitate noninvasive and serial quantification of inflammation severity, offering the opportunity to predict eventual outcome, stratify patient risk, and guide novel targeted molecular therapies against specific leukocyte subpopulations. Here, we will discuss the established and emerging nuclear imaging methods to label and track exogenous and endogenous immune cells, with a particular focus on clinical situations in which targeted molecular inflammation imaging would be advantageous. The expanding options for imaging inflammation provide the foundation to bridge between molecular imaging and individual therapy.

Source: Circulation Cardiovascular Imaging

DOI: 10.1161/circimaging.122.014067

Authors: Gyu Seong Heo, Johanna Diekmann, James T. Thackeray, Yongjian Liu

Institutions: Washington University in St. Louis, Medizinische Hochschule Hannover

Language: English

Topic: Cardiac Imaging and Diagnostics

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering