Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts
Year: 2023
Type: article
Abstract: Objective To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). Design Pooled analysis. Data sources A consortium of 19 studies from 12 countries identified up to May 2020. Study selection Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. Data extraction and synthesis Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. Main outcome measures Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m 2 . In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m 2 and <75% of baseline rate. Results 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I 2 =9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I 2 =0.0%). Plant derived α linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I 2 =5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (≥60 v <60 years), estimated glomerular filtration rate (60-89 v ≥90 mL/min/1.73 m 2 ), hypertension, diabetes, and coronary heart disease at baseline. Conclusions Higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. These results support a favourable role for seafood derived n-3 PUFAs in preventing CKD.
Source: BMJ
Authors: Kwok Leung Ong, Matti Marklund, Liping Huang, Kerry-Anne Rye, Nicholas Hui, Xiong-Fei Pan, Casey M Rebholz, Hyunju Kim, Lyn M Steffen, Anniek C van Westing, Johanna M Geleijnse, Ellen K Hoogeveen, Yun-Yu Chen, Kuo-Liong Chien, Amanda M Fretts, Rozenn N Lemaitre, Fumiaki Imamura, Nita G Forouhi, Nicholas J Wareham, Anna Birukov, Susanne Jäger, Olga Kuxhaus, Matthias B Schulze, Vanessa Derenji de Mello, Jaakko Tuomilehto, Matti Uusitupa, Jaana Lindström, Nathan Tintle, William S Harris, Keisuke Yamasaki, Yoichiro Hirakawa, Toshiharu Ninomiya, Toshiko Tanaka, Luigi Ferrucci, Stefania Bandinelli, Jyrki K Virtanen, Ari Voutilainen, Tharusha Jayasena, Anbupalam Thalamuthu, Anne Poljak, Sonia Bustamante, Perminder S Sachdev, Mackenzie K Senn, Stephen S Rich, Michael Y Tsai, Alexis C Wood, Markku Laakso, Maria Lankinen, Xiaowei Yang, Liang Sun, Huaixing Li, Xu Lin, Christoph Nowak, Johan Ärnlöv, Ulf Risérus, Lars Lind, Mélanie Le Goff, Cécilia Samieri, Catherine Helmer, Frank Qian, Renata Micha, Adrienne Tin, Anna Köttgen, Ian H de Boer, David S Siscovick, Dariush Mozaffarian, Jason HY Wu
Institutions: UNSW Sydney, Uppsala University, Johns Hopkins University, The George Institute for Global Health, Sichuan University, West China Second University Hospital of Sichuan University, University of Minnesota, Wageningen University & Research, National Taiwan University, Taipei Veterans General Hospital, Taichung Veterans General Hospital, Jeroen Bosch Ziekenhuis, National Institutes of Health, University of Washington, University of Cambridge, MRC Epidemiology Unit, German Center for Diabetes Research, German Institute of Human Nutrition, University of Potsdam, University of Eastern Finland, University of Helsinki, King Abdulaziz University, Finnish Institute for Health and Welfare, University of Illinois Chicago, Fatty Acid Research Institute, Kyushu University, University of South Dakota, National Institute on Aging, Azienda Usl Toscana Centro, Centre for Healthy Brain Ageing, Mark Wainwright Analytical Centre, Baylor College of Medicine, Children's Nutrition Research Center at Baylor College of Medicine, University of Virginia, Kuopio University Hospital, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Karolinska Institutet, Université de Bordeaux, Inserm, Bordeaux Population Health, Beth Israel Deaconess Medical Center, Harvard University, Tufts University, University of Thessaly, University of Mississippi Medical Center, University of Freiburg, University Medical Center Freiburg, VA Puget Sound Health Care System, New York Academy of Medicine
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Funders: U.S. Department of Health and Human Services, U.S. Department of Agriculture, Bill and Melinda Gates Foundation, Rockefeller Foundation, AstraZeneca, Biogen, Kaiser Permanente, Wake Forest University, University of Minnesota, Danone, University of Washington, Johns Hopkins University, University of South Dakota, National Institute for Health and Care Research, Deutsche Forschungsgemeinschaft, Ministry of Education, Culture, Sports, Science and Technology, University of New South Wales, National Science Council, Chinese Academy of Sciences, Nierstichting, Ministero della Salute, Ministry of Health, Labour and Welfare, Kuopion Yliopistollinen Sairaala, Vetenskapsrådet, Ministry of Science and Technology, Taiwan, Universidad de Antioquia, National Taiwan University Hospital, National Taiwan University, Uppsala Universitet, Jaap Schouten Foundation, National Institutes of Health, University of California, Los Angeles, Agricultural Research Service, Johns Hopkins Bloomberg School of Public Health, Medical Research Council, National Health and Medical Research Council, Japan Society for the Promotion of Science, NIHR Cambridge Biomedical Research Centre, National Institute on Aging, National Heart, Lung, and Blood Institute
Awards: G1090328858, Cross-sectional and prospective studies of the elucidation of actual status of dementia in a Japanese older residents., G1248102086, G1409796352, G1698328007, G1761781424, G1789381357, Association between psychosocial factors and lifestyle-related diseases in a community-dwelling Japanese population: the Hisayama Study, 生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究, G2243371366, Alpha Omega Trial, G2495888254, G259853090, Development of predictive indicators and treatment strategies for dementia associated with diabetes and obesity focusing TREM2 and monocyte function, G2857511458, G2934883841, G3117239229, G3249287529, G3303013554, G3362311673, G374919288, G402067665, G4109153585, G4122201895, G4507648799, G4652745033, Secular trends in the prevalence, incidence and risk factor of diabetic retinopathy: the Hisayama study, Molecular epidemiology of virulence of microbiome considering host immune response, G4940211717, Construction of a preventive approach for chronic lung diseases based on a maintenance of tongue microbiota, G5038676132, 小麦属フエレドキシンの比較生化学的研究, Development of a predictive model for future functional disability among community-dwelling elderly and its social implementation, G5808285546, G5830315508, G5883489846, G6040590961, G6107810936, G6145130349, G631129105, G6985848564, Integration of out-of-office blood pressure for investigating comprehensive risk on cardiovascular complications., Prospective study on the association of active commuting and diabetes incidence, G7333524540, G7488292445, G7519571385, Identification of novel biomarkers and risk factors for cardiovascular disease, G8295864851, G8355640939, Biomakers and genetic factors for the development of atrial fibrillation in a general population: the Hisayama Study, G8993279099, G8993694303, G931188625, G93682057
OpenAlex ID: W4317366331