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TGFBR1*6A and breast tumor fibrosis

Year: 2023
Type: preprint
Study design: Observational Study
Abstract: Dense fibrosis of the breast as assessed by mammography may be associated with early disease diagnosis. Radiation-induced fibrosis occurs in a large fraction of patients following breast conserving therapy and may be modified by genetic susceptibility. TGFBR1*6A is a high frequency, low penetrance TGFBR1 hypomorphic variant, which is associated with breast cancer risk. Here we show an association of TGFBR1*6A with breast cancer tissue fibrosis in mice and in patients with HER2-positive breast cancer.
DOI: 10.21203/rs.3.rs-2436926/v1
Authors: Boris Pasche, Kojo Agyemang, Grayson Barker, Allan Johansen, Kimberly Sheffield, Wencheng Li, Paul Grippo, Virginia Kaklamani, Kounosuke Watabe, Antonio Di Cristofano
Institutions: Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Wake Forest University, University of Illinois Chicago, The University of Texas at San Antonio Health Science Center, Albert Einstein College of Medicine
Language: English
Open Access status: green
OpenAlex ID: W4317376270
Cites: 16
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Related to: 10