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Racial and ethnic disparities in a real-world precision oncology data registry

Year: 2023
Type: article
Abstract: Biorepositories enable precision oncology research by sharing clinically annotated genomic data, but it remains unknown whether these data registries reflect the true distribution of cancers in racial and ethnic minorities. Our analysis of Project Genomics Evidence Neoplasia Information Exchange (GENIE), a real-world cancer data registry designed to accelerate precision oncology discovery, indicates that minorities do not have sufficient representation, which may impact the validity of studies directly comparing mutational profiles between racial/ethnic groups and limit generalizability of biomarker discoveries to all populations.
DOI: 10.1038/s41698-023-00351-6
Authors: Alexander T. M. Cheung, Elina L. Palapattu, Isabella R. Pompa, Christopher M. Aldrighetti, Andrzej Niemierko, Henning Willers, Franklin Huang, Neha Vapiwala, Eliezer Van Allen, Sophia C. Kamran
Institutions: Broad Institute, New York University, Dana-Farber Cancer Institute, Harvard University, Massachusetts General Hospital, University of California, San Francisco, Hospital of the University of Pennsylvania
Language: English
Subfield: Cancer Research
Open Access status: gold
Estimated APC paid: $3,490
OpenAlex ID: W4317435826
FWCI: 3.683
Cites: 20
Cited by: 38
Related to: 10