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Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Year: 2023
Type: review
Study design: Systematic Review
Abstract: A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.
Source: Cells
DOI: 10.3390/cells12030383
Authors: Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjørklund
Institutions: Karaganda Medical University, Nazarbayev University, Astana Medical University, Semey Medical University, BAU International University, Batumi, Al-Farabi Kazakh National University, Council for Nutritional and Environmental Medicine
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,669
OpenAlex ID: W4317608987
FWCI: 1.138
Cites: 95
Cited by: 33
Related to: 10