Work

Analysis of Interleukin-17, Interleukin-23, neopterin and Nesfatin-1 levels in the sera of Hashimoto patients

Year: 2023

Type: article

Abstract: Background: Hashimoto's thyroiditis (HT) is an autoimmune disorder affecting the thyroid gland and may present as goiter or atrophic thyroiditis that may result in various metabolic and inflammatory disorders. The aim of this study is to determine the changes in serum levels of interleukin-17 (IL-17), IL-23, neopterin, and nesfatin-1 parameters in HT patients and to evaluate the possible relationship among these parameters. Methods: 90 HT patients and 30 healthy individuals were included in this study. Demographic data of the patients included in the study were recorded and detailed physical examinations were performed. IL-17, IL-23, neopterin, and nesfatin-1 levels were measured in the serum samples of the participants by the ELISA method. Results: Serum IL-17, IL-23, neopterin, levels were significantly higher and nesfatin-1 levels were significantly lower in the HT group compared to the control group. Statistically significant differences were observed between all the groups except euthyroid HT versus HT treated with levothyroxine for nesfatin-1 at the 0.05 level. Conclusion: IL-17, IL-23, and neopterin were involved in the etiopathogenesis of HT. Weight gain in HT may due to low nesfatin-1 level rather than throid hormone deficiency. These variables could be used as potential biomarkers in the diagnosis, prognosis and fellow up of HT disease.

Source: Journal of Medical Biochemistry

DOI: 10.5937/jomb0-40683

Authors: Nihayet Bayraktar, Mehmet Eren, Mustafa Bayraktar, Ali Öztürk, Hamza Erdoğdu

Institutions: Harran University, Ankara Yıldırım Beyazıt University, Niğde Ömer Halisdemir Üniversitesi

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Harran Üniversitesi