Work

Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in patients with chronic myeloid leukemia

Year: 2023

Type: article

Abstract: In this study, we have shown that non-diabetic patients with CML receiving nilotinib therapy show early signs of disturbed skeletal muscle glucose handling, which was not observed in imatinib-treated patients. These observations in nilotinib users may reflect decreased muscle insulin sensitivity, which could serve as a potential target to counteract glycemic dysregulation, and is of clinical importance since these patients have an increased cardiovascular disease risk.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00163.2022

Authors: Lando Janssen, Maria T. E. Hopman, Greetje J. A. Swaans, Neeltje A. E. Allard, Marti Boss, Daphne Lobeek, Martin Gotthardt, Tom J. J. Schirris, Nicole M. A. Blijlevens, Silvie Timmers

Institutions: Radboud University Medical Center, Radboud Institute for Health Sciences, Radboud Institute for Molecular Life Sciences, Wageningen University & Research

Language: English

Topic: Chronic Myeloid Leukemia Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4318021316

FWCI: 2.263

Cites: 33

Cited by: 11

Related to: 10