Work

Immunotherapy for Hepatocellular Carcinoma in the Setting of Liver Transplantation: A Review

Year: 2023

Type: review

Abstract: The emerging field of immuno-oncology has brought exciting developments in the treatment of hepatocellular carcinoma (HCC). It has also raised urgent questions about the role of immunotherapy in the setting of liver transplantation, both before and after transplant. A growing body of evidence points to the safety and efficacy of immunotherapeutic agents as potential adjuncts for successful down-staging of advanced HCCs to allow successful transplant in carefully selected patients. For patients with recurrent HCC post-transplant, immunotherapy has a limited, yet growing role. In this review, we describe optimal regimens in the setting of liver transplantation.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms24032358

Authors: Zurabi Lominadze, Kareen Hill, Mohammed Rifat Shaik, Justin P. Canakis, Mohammad Bourmaf, Cyrus Adams-Mardi, Ameer Abutaleb, Lopa Mishra, Kirti Shetty

Institutions: University of Maryland, Baltimore, University of Maryland Medical Center, University of Maryland Medical Center Midtown Campus, George Washington University, Northwell Health, Feinstein Institute for Medical Research, Cold Spring Harbor Laboratory

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,780

Funders: National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute

Awards: Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer, Cellular interactions between TGF-beta pathway members and epigenetic regulators in liver and gastrointestinal cancers, Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation

OpenAlex ID: W4318053959

FWCI: 0.559

Cites: 103

Cited by: 13

Related to: 10