Year: 2023
Type: article
Abstract: Rationale COPD is the third leading cause of death in the United States. Sphingolipids, structural membrane constituents that play a role in cellular stress and apoptosis signalling, may be involved in lung function. Methods In the Cardiovascular Health Study, a prospective cohort of older adults, we cross-sectionally examined the association of plasma levels of 17 sphingolipid species with lung function and COPD. Multivariable linear regression and logistic regression were used to evaluate associations of sphingolipid concentrations with forced expiratory volume in 1 s (FEV1) and odds of COPD, respectively. Results Of the 17 sphingolipids evaluated, ceramide-18 (Cer-18) and sphingomyelin-18 (SM-18) were associated with lower FEV1values (–0.061 L per two-fold higher Cer-18, p=0.001; −0.092 L per two-fold higher SM-18, p=0.002) after correction for multiple testing. Several other associations were significant at a 0.05 level, but did not reach statistical significance after correction for multiple testing. Specifically, Cer-18 and SM-18 were associated with higher odds of COPD (odds ratio per two-fold higher Cer-18 1.29, p=0.03 and SM-18 1.73, p=0.008). Additionally, Cer-16 and SM-16 were associated with lower FEV1values, and Cer-14, SM-14 and SM-16 with a higher odds of COPD. Conclusion In this large cross-sectional study, specific ceramides and sphingomyelins were associated with reduced lung function in a population-based study. Future studies are needed to examine whether these biomarkers are associated with longitudinal change in FEV1within individuals or with incident COPD.
Source: ERJ Open Research
Institutions: University of Washington, New York Academy of Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $808
Awards: CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1338207769, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, Plasma Sphingolipids and Subclinical and Clinical Cardiovascular Disease, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, CHS research resources for the cardiovascular health of older adults, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Sphingolipids, Diabetes, and Cardiovascular Disease, G5251985303, CHS Events Follow-up Study, Plasma sphingolipids and risk of cardiovascular disease, G634386134, G8260701975, CHS-Transition Phase -268055222, G9000000312, G9000027259, G9000046001, G9000069887, G9000071222, G9000124008, G9000139054, G9000155215, Nutrition Obesity Research Center, Diabetes Research Center
OpenAlex ID: W4318070525