Year: 2023
Type: article
Abstract: Targeted temperature management (TTM) is standard of care for neonatal hypoxic ischemic encephalopathy (HIE). Prevention of fever, not excluding cooling core body temperature to 33°C, is standard of care for brain injury post cardiac arrest. Although TTM is beneficial, HIE and cardiac arrest still carry significant risk of death and severe disability. Mammalian hibernation is a gold standard of neuroprotective metabolic suppression, that if better understood might make TTM more accessible, improve efficacy of TTM and identify adjunctive therapies to protect and regenerate neurons after hypoxic ischemia brain injury. Hibernating species tolerate cerebral ischemia/reperfusion better than humans and better than other models of cerebral ischemia tolerance. Such tolerance limits risk of transitions into and out of hibernation torpor and suggests that a barrier to translate hibernation torpor may be human vulnerability to these transitions. At the same time, understanding how hibernating mammals protect their brains is an opportunity to identify adjunctive therapies for TTM. Here we summarize what is known about the hemodynamics of hibernation and how the hibernating brain resists injury to identify opportunities to translate these mechanisms for neurocritical care.
Source: Frontiers in Neurology
Authors: Kelly L. Drew, Saurav Bhowmick, Bernard W. Laughlin, Anna V. Goropashnaya, Øivind Tøien, M. Hoshi Sugiura, Ardy Wong, Kambiz Pourrezaei, Zeinab Barati, Chao-Yin Chen
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Funders: National Aeronautics and Space Administration, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, Office of Experimental Program to Stimulate Competitive Research
Awards: SPANNING THE NORTHERN ARCTIC AND SUBARCTIC REGIONS ALASKA IS STRATEGICALLY LOCATED TO SUPPORT NASA MISSIONS ACROSS ALL DIRECTORATES. ALASKA IS HOME TO SEVERAL SATELLITE TRACKING STATIONS WHICH TRACK AND DOWNLOAD DATA FROM COMMERCIAL AND SCIENTIFIC SATELLITES. ALASKA OWNS AND OPERATES THE KODIAK LAUNCH COMPLEX A FACILITY CAPABLE OF LAUNCHING SCIENTIFIC AND COMMERCIAL PAYLOADS TO ORBIT. THE UNIVERSITY OF ALASKA FAIRBANKS OPERATES THE ONLY UNIVERSITY OWNED ROCKET RANGE IN THE NATION PROVIDING SUBORBITAL SCIENTIFIC ROCKET LAUNCHES IN SUPPORT OF RESEARCH ON THE ARCTIC ATMOSPHERE IONOSPHERE AND AURORA. ALASKA IS AN IDEAL LOCATION TO PERFORM GROUND TRUTH CALIBRATION OF EARTH OBSERVING SATELLITES AND MODELS FOR THE ARCTIC AND SUBARCTIC REGIONS WHERE THERE IS A PAUCITY OF SUCH MEASUREMENTS. AS A LIVING LAB ALASKA PROVIDES A HARSH ISOLATED ENVIRONMENT WHICH CAN BE USED TO INFORM AND EVALUATE TECHNOLOGIES NECESSARY FOR FUTURE OFF WORLD BASES. WE ARE THE CANARY IN THE COAL MINE CURRENTLY FEELING THE EFFECTS OF GLOBAL CLIMATE CHANGE AND PLANNING THE RELOCATION OF RURAL VILLAGES SHISHMAREF KIVALINA AND NEWTOK. THIS NASA EPSCOR RID PROPOSAL SEEKS TO BUILD ALASKA S RESEARCH INFRASTRUCTURE AND TECHNOLOGY CAPABILITIES BY PROVIDING SEED FUNDING AND INCENTIVES THAT WILL LEAD TOWARD LONG-TERM SELF-SUSTAINING NATIONALLY-COMPETITIVE CAPABILITIES IN SUPPORT OF NASA RELATED RESEARCH AND TECHNOLOGY PRIORITIES., G2859671241, G3996337124, G5552027144, Mammalian Hibernation Research- A Path Towards a Center for Transformative Research in Metabolism, G9000064077, G9000201822, G9000263192
OpenAlex ID: W4318192598