Work

Ambient fine particulate exposure and subcortical gray matter microarchitecture in 9- and 10-year-old children across the United States

Year: 2023

Type: article

Abstract: Neuroimaging studies showing the adverse effects of air pollution on neurodevelopment have largely focused on smaller samples from limited geographical locations and have implemented univariant approaches to assess exposure and brain macrostructure. Herein, we implement restriction spectrum imaging and a multivariate approach to examine how one year of annual exposure to daily fine particulate matter (PM 2.5 ), daily nitrogen dioxide (NO 2 ), and 8-h maximum ozone (O 3 ) at ages 9-10 years relates to subcortical gray matter microarchitecture in a geographically diverse subsample of children from the Adolescent Brain Cognitive Development (ABCD) Study ℠ . Adjusting for confounders, we identified a latent variable representing 66% of the variance between one year of air pollution and subcortical gray matter microarchitecture. PM 2.5 was related to greater isotropic intracellular diffusion in the thalamus, brainstem, and accumbens, which related to cognition and internalizing symptoms. These findings may be indicative of previously identified air pollution-related risk for neuroinflammation and early neurodegenerative pathologies.

Source: iScience

DOI: 10.1016/j.isci.2023.106087

Authors: Kirthana Sukumaran, Carlos Cardenas-Iniguez, Elisabeth Burnor, Katherine L. Bottenhorn, Daniel A. Hackman, Rob McConnell, Kiros Berhane, Joel Schwartz, Jiu-Chiuan Chen, Megan M. Herting

Institutions: University of Southern California, Florida International University, Columbia University, Harvard University, Children's Hospital Los Angeles

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,150

Funders: National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences

Awards: Urban air pollution and neurobehavioral trajectories in the ABCD study, ABCD Workshop on Brain Development in Relation to Mental Health, Harvard Chan School NIEHS Center for Environmental Health, Modeling Developmental Change in the ABCD Study: Longitudinal Analyses for Clinical Outcomes, A Longitudinal Mentoring Approach to Increase Diversity Among Researchers of Neurological Disorders, The role of air pollution in emotional neurodevelopment and risk for psychiatric disorders, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 3/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MINNESOTA, 4/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT FIU, 7/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT YALE, Environmental Exposures, Host Factors and Human Disease, BRAINS: Broadening the Representation of Academic Investigators in NeuroSciences - A national program to increase the advancement of neuroscience researchers from diverse backgrounds, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, ABCD-USA Consortium: Coordinating Center, Neuroscience Scholars Program (NSP): Preparing the Next Generation of Neuroscience Leaders, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 10/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI, 12/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U PITTSBURGH, 1/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U UTAH, ABCD-USA Consortium: Data Analysis, Informatics and Resource Center, 5/21 ABCD-USA Consortium: Research Project Site at UC San Diego, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB

OpenAlex ID: W4318612580

FWCI: 3.323

Cites: 117

Cited by: 29

Related to: 10