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Nucleophilic Addition of 4,5-Dihydrooxazole Derivatives to Base Generated o-Quinone Methides: A Four-Component Reaction

Year: 2023

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A novel method for joining four components together in a single pot leading to an assortment of N-amino-benzylated phenols is described. The method involves the addition of different Grignard reagents to various o -OBoc salicylaldehydes in the presence of assorted 4,5-dihydrooxazoles, followed by aqueous workup. Seventeen examples are presented with varied (-R, -R′ -R″, -R‴, -R⁗, and C n ) substituents.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.2c02614

Authors: Yuk Fai Wong, Ivan Hernandez, Thomas R. R. Pettus

Institution: University of California, Santa Barbara

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funder: University of California, Santa Barbara