Sex-specific associations of reservoir–excess pressure parameters with age and subclinical vascular remodeling
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Central artery reservoir pressure and excess pressure (XSP) are associated with cardiovascular disease (CVD) events and mortality. However, sex differences in the trajectory of central reservoir pressure and XSP with advancing age and their relations with vascular markers of subclinical CVD risk are incompletely understood. Therefore, we tested the hypothesis that central reservoir pressure and XSP would be positively associated with advancing age and vascular markers of subclinical CVD risk in men and women. METHOD: Healthy adults ( n = 398; aged 18-80 years, 60% female individuals) had central (carotid) artery pressure waveforms acquired by applanation tonometry. Reservoir pressure and XSP peaks and integrals were derived retrospectively from carotid pressure waveforms using custom written software. Carotid artery intimal-medial thickness (IMT) was measured by ultrasonography, and aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV). RESULTS: Reservoir pressure peak, reservoir pressure integral and XSP integral were higher with age in both men and women ( P < 0.05), whereas XSP peak was lower with age in men ( P < 0.05). In women, both reservoir pressure peak ( β = 0.231, P < 0.01) and reservoir pressure integral ( β = 0.254, P < 0.01) were associated with carotid artery IMT, and reservoir pressure peak was associated with cfPWV ( β = 0.120, P = 0.02) after adjusting for CVD risk factors. CONCLUSION: Central artery reservoir pressure and XSP were higher with advancing age in men and women, and reservoir pressure peak was associated with both carotid artery wall thickness and aortic stiffness in women but not men. Central reservoir pressure peak may provide some insight into sex differences in vascular remodeling and subclinical CVD risk with advancing age in healthy adults.
Source: Journal of Hypertension
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1567652797, University of Iowa Clinical and Translational Science Program (KL2), Targeting Inflammation to Treat Cardiovascular Aging in Humans, Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic Hypertension, Mechanisms of Early and Late Postpartum Hypertension in Human Preeclampsia, Anxiety-mediated impairments in large elastic artery function and the autonomic nervous system, Iowa Training Program in Kidney and Hypertension Research, Integrative Neurobiology of Cardiovascular Regulation, G5440672023, Inorganic Nitrate, Large Artery Stiffness and Cerebral Blood Flow in Aged Humans, Bridging acute and long-term exercise effects on brain function in older adults, Exercise to improve hippocampal connectivity and learning in older adults, Cardiovascular Institutional Research Fellowship, The University of Iowa Clinical and Translational Science Award, G9000139622, G9000149602, University of Iowa Institute for Clinical and Translational Science
OpenAlex ID: W4318755763