Work

Predominance of High-Level Tetracycline-Resistant Neisseria gonorrhoeae in Kenya: Implications for Global Implementation of Doxycycline Postexposure Prophylaxis for Prevention of Sexually Transmitted Infections

Year: 2023

Type: article

Abstract: ABSTRACT: Using archived Neisseria gonorrhoeae samples from 2008 to 2012, the prevalence of tet (M) genemediating high-level tetracycline resistance in N. gonorrhoeae was 96% among 50 Kenyan women. Determining the local and national prevalence of gonococcal tetracycline resistance and surveillance of gonococcal antimicrobial resistance can inform the implementation of doxycycline postexposure prophylaxis for STI prevention.

Source: Sexually Transmitted Diseases

DOI: 10.1097/olq.0000000000001769

Authors: Olusegun O. Soge, Rodal Issema, Elizabeth Bukusi, Jared M. Baeten, Andrew Mujugira, Connie Celum, R. Scott McClelland, Jenell Stewart, for the Partners PrEP Study Team

Institutions: University of Washington, Harborview Medical Center, Kenya Medical Research Institute, Infectious Diseases Institute, Makerere University, University of Minnesota, Hennepin Healthcare Research Institute

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Gilead Sciences, University of Washington, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases

Awards: PrEP and dPEP: Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis, Exploration of the oropharyngeal resistome as a reservoir of antimicrobial resistance in Neisseria gonorrhoeae, Understanding STI and HIV prevention adherence among Kenyan women, University of Washington/Fred Hutch Center for AIDS Research

OpenAlex ID: W4318913138

FWCI: 3.824

Cites: 24

Cited by: 21

Related to: 10