Work

Plasmonic quenching and enhancement: metal–quantum dot nanohybrids for fluorescence biosensing

Year: 2023

Type: article

Abstract: nanosurface energy transfer (NSET) or Förster resonance energy transfer (FRET) offers powerful ways of tuning and amplifying optical signals and is relatively common, metal-QD nanohybrids for plasmon-enhanced fluorescence (PEF) have been much less prevalent. A major reason is the competition between fluorescence quenching and enhancement, which poses important challenges for optimizing distances, orientations, and spectral overlap toward maximum PEF. In this feature article, we discuss the interplay of the different quenching and enhancement mechanisms (a mixed distance dependence of quenching and enhancement - "quenchancement") to better understand the obstacles that must be overcome for the development of metal-QD nanohybrid-based PEF biosensors. The different nanomaterials, their combination within various surface and solution based design concepts, and their structural and photophysical characterization are reviewed and applications toward advanced optical biosensing and bioimaging are presented along with guidelines and future perspectives for sensitive, selective, and versatile bioanalytical research and biomolecular diagnostics with metal-QD nanohybrids.

Source: Chemical Communications

DOI: 10.1039/d2cc06178c

Authors: Niko Hildebrandt, Mihye Lim, Namjun Kim, Da Yeon Choi, Jwa-Min Nam

Institution: Seoul National University

Language: English

Topic: Plasmonic and Surface Plasmon Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Research Foundation, National Research Foundation of Korea, Ministry of Science and ICT, South Korea