Work

Everybody needs good neighbours: the progressive DCIS microenvironment

Year: 2023

Type: review

Abstract: Ductal carcinoma in situ (DCIS) is a pre-invasive form of breast cancer where neoplastic luminal cells are confined to the ductal tree. While as many as 70% of DCIS cases will remain indolent, most women are treated with surgery, often combined with endocrine and radiotherapies. Overtreatment is therefore a major issue, demanding new methods to stratify patients. Somewhat paradoxically, the neoplastic cells in DCIS are genetically comparable to those in invasive disease, suggesting the tumour microenvironment is the driving force for progression. Clinical and mechanistic studies highlight the complex DCIS microenvironment, with multiple cell types competing to regulate progression. Here, we examine recent studies detailing distinct aspects of the DCIS microenvironment and discuss how these may inform more effective care.

Source: Trends in cancer

DOI: 10.1016/j.trecan.2023.01.002

Authors: Shayin V. Gibson, Reza M. Roozitalab, Michael D. Allen, J. Louise Jones, Edward P. Carter, Richard P. Grose

Institutions: Queen Mary University of London, Barts Cancer Institute

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,830