Year: 2023
Type: editorial
Abstract: Developmental endocrinology research is exciting; the subject is full of intriguing biographical history (1).I first heard of "Developmental Endocrinology" in 1986 when I began to work at the USA National Institutes of Health, Bethesda, Maryland.My work was as a research fellow in the Developmental Endocrinology Branch.D. Lynn Loriaux, MD, Ph.D., served as the Branch Chief and Institute Clinical Director.What a rich academic environment he provided.The Branch comprised basic laboratory scientists and world leaders in clinical research in endocrinology -pediatric, medical, and reproductive.Notably, the long-term funding provided by the NIH Intramural Research Program permitted investigators to conduct in-depth studies of rare disorders, sometimes over several decades.For example, this funding model permitted me to build a team to research the rare disorder of Primary Ovarian Insufficiency for the next 30 years.More about this in due course.This Research Topic reports on new insights, challenges, and future perspectives across a broad range of critical biological issues.For example, we learn about the cellular response to hypoxia in developing zebrafish, exosomal RNAs in pregnant women with diabetes, the evolution of placental endocrinology, ultrasound criteria of polycystic ovary syndrome, and research on the rare disorder Primary Ovarian Insufficiency (POI).Zasu et al. study oxygen deprivation, which induces multiple changes at the cellular and organismal levels, and its re-supply also brings another special physiological status.This research team investigated the effects of hypoxia/re-oxygenation on embryonic growth using the zebrafish model: hypoxia slows embryonic growth, but re-oxygenation induces growth spurt or catch-up growth.Their results indicate that redox signaling alters IGF/Igf signaling to facilitate hypoxia/re-oxygenation-induced embryonic growth compensation.Yuan et al. studied exosomes, cell-derived vesicles in many biological fluids.For example, exosomal RNAs in cord blood may allow intercellular communication between mother and fetus.Notably, their results show the aberrant expression of exosomal RNAs in the cord blood of patients with gestational diabetes mellitus (GDM).Furthermore, the findings may highlight essential aspects of exosomal RNAs in the peripheral blood of women with GDM.
Source: Frontiers in Endocrinology
Author: Lawrence M. Nelson
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Funder: National Institutes of Health
OpenAlex ID: W4318995189