Work

Unraveling multilayered extracellular vesicles: Speculation on cause

Year: 2023

Type: article

Abstract: Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

Source: Journal of Extracellular Vesicles

DOI: 10.1002/jev2.12309

Authors: Kelly Broad, Sierra A. Walker, Irina Davidovich, Kenneth Witwer, Yeshayahu Talmon, Joy Wolfram

Institutions: Mayo Clinic, University of Florida, Mayo Clinic in Florida, Technion – Israel Institute of Technology, Johns Hopkins University, Johns Hopkins Medicine, Houston Methodist, The University of Queensland, Houston Methodist Research Institute

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,200

Funders: University of Queensland, Israel Science Foundation, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G3920254259, Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates, Next-generation extracellular vesicle biologics to target central nervous system and peripheral reservoirs of HIV, Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette Use, Novel Approaches to Capture, Sorting, and Characterization of CNS-Origin Extracellular Vesicles

OpenAlex ID: W4319063526

FWCI: 4.633

Cites: 56

Cited by: 52

Related to: 10