A Single-Arm, Multicenter, Exploratory, Safety and Efficacy Study of FCR001 Cell-Based Therapy to Induce Donor-Specific Tolerance in Previously Transplanted Recipients of a Kidney from a Living Donor, and Safety in FCR001 Donors (FREEDOM-2 study)
Year: 2023
Type: article
Abstract: Detailed knowledge regarding the nature of and mechanisms causing neutron irradiation damage in graphite remains a scientific and technological challenge, particularly at high irradiation doses. Using electrons as a surrogate for neutron irradiation, we develop a time-dependent atomistic reconstruction strategy fed by a time series of high-resolution transmission electron microscopy (HRTEM) images, to monitor damage propagation in a graphite grain up to a dose of about one displacement per atom (i.e. well beyond the conventional irradiation simulations based on molecular dynamics). The reduction in crystalline order and the development of interlayer bonding observed in the models with increasing irradiation time induce significant modifications of the elastic constants and thermal conductivity. Homogenizing these properties to the case of isotropic polycrystalline graphite we are able to reproduce the increase in Young's modulus and decrease in thermal conductivity observed experimentally for reactor graphites with increasing dose. Further validation of the models is provided via a comparison of simulated and experimental data from irradiated material such as: HRTEM images, carbon K-edge electron energy loss spectra, dose rate and stored energies.
Authors: Joseph R. Leventhal, Lawrence Chodoff, Kristi Schneider, Nancy R Krieger, Suzanne T Ildstad
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W4319263480