Work

Alphafold prediction of the Plasmodium TRAP I domain for mutants design.

Year: 2023

Type: article

Abstract: Plasmodium sporozoites have several surface proteins, including the single-pass transmembrane adhesin thrombospondin related anonymous protein (TRAP). TRAP harbors two extracellular domains, the I-domain and the thrombospondin type I repeat, TSR. TRAP I domain in the “closed” conformation is unbound and has low adhesion and no signaling activity. We use Alphafold to predict the Plasmodium TRAP I domain for mutants design. Here is the Alphafold predicted structures of the TRAP I domain.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.7613486

Authors: Braumann, Friedrich, Klug, Dennis, Kehrer, Jessica, Springer, Timothy A., Frischknecht, Friedrich

Institutions: Heidelberg University, Boston Children's Hospital, Harvard University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W4319332380

FWCI:

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