Work

Research progress in Th17 cells and the relevant cytokines in Graves' ophthalmopathy.

Year: 2022

Type: article

Abstract: Graves' ophthalmopathy is the most common clinical orbital disease, and T helper (Th) cells play an important role in the development of Graves' ophthalmopathy. Th17 cells are a major subpopulation of Th cells and abnormally highly expressed in patients with Graves' ophthalmopathy. Th17 cells and the related cytokines interleukin (IL)-17A, IL-21 and IL-23 are involved in regulating the inflammatory response, fibrosis and adipogenesis. Th17 cells are unstable and exhibit a degree of plasticity, and they can differentiate into IL-17A and interferon (IFN)-γ dual-producing Th17.1 cells, which exacerbate the pathogenicity of Th17 cells. In addition, Th17 cells and the relevant factors are strongly associated with disease activity and severity in Graves' ophthalmopathy.

Source: PubMed

DOI: 10.11817/j.issn.1672-7347.2022.220205

Authors: Minmin Jiang, Jingxiao Zhao, Ping Wang, Shuxun Yan, Ying Wang

Institutions: Henan University of Traditional Chinese Medicine, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Ophthalmology and Eye Disorders

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4319333027

FWCI: 0.282

Cites: 36

Cited by: 2

Related to: 10