Year: 2023
Type: article
Abstract: The emergence of highly immune-escape Omicron variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BQ and XBB, has led to concerns about the efficacy of vaccines. Using lentivirus-based pseudovirus neutralizing assay, we showed that heterologous vaccination involving parental mRNA vaccine as a booster or second booster in individuals that received two or three doses of inactivated vaccines strongly augments the neutralizing activity against emerging Omicron subvariants, including BF.7, BQ.1.1, and XBB.1, by 4.3-to 219-folds. Therefore, a heterologous boosting strategy with mRNA-based vaccines should be considered in populations where inactivated vaccines were primarily used.
Authors: Fanglei Zuo, Rui Sun, Hassan Abolhassani, Likun Du, Yating Wang, Stelios Vlachiotis, Federico Bertoglio, Maren Schubert, Nima Rezaei, Zahra Chavoshzadeh, Concetta Guerra, Andrea Cavalli, Juni Andréll, Makiko Kumagai-Braesch, Yintong Xue, Yunlong Cao, Michael Hust, Davide F. Robbiani, Xiaoliang Sunney Xie, Lennart Hammarström, Harold Marcotte, Qiang Pan-Hammarström
Institutions: Karolinska Institutet, Technische Universität Braunschweig, Children's Medical Center, Tehran University of Medical Sciences, Shahid Beheshti University of Medical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana, Stockholm University, Science for Life Laboratory, Karolinska University Hospital, Peking University, Changping Laboratory
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,680
OpenAlex ID: W4365143472