Work

The immunological profiles of T-cell large granular lymphocyte leukemia: results from a single center in China

Year: 2023

Type: preprint

Abstract: To characterize the immunological profiles of T-cell large granular lymphocyte leukemia (T-LGLL) in China, we studied and correlated the proportion among T lymphocyte subsets, CD3−CD16/CD56+ NK and CD19+ B cells in 39 T-LGLL patients. Our study identified increased percentage and absolute number of CD3+CD8+ T cells, meanwhile decreased CD3+CD4+ T cells and CD4/CD8 ratio in T-LGLL cases. Interestingly, there were significant correlations between CD3+CD8+ T cells and T-cell large granular lymphocyte (T-LGL). The significantly decreased percentage and absolute number of normal CD3−CD16/CD56+ NK and CD19+ B cells, which were significant correlations with CD3+CD4+ T, CD3+CD8+ T or CD4/CD8 ratios, were observed. Also we found that the percentage of CD3+CD8+ T cells in αβ T-LGLL was significantly higher than that in γδ T-LGLL. Thus, changes of T lymphocyte subsets, normal NK and B cells, and the correlations among them in Chinese patients with T-LGLL were determined.

Source: Research Square

DOI: 10.21203/rs.3.rs-2550159/v1