Year: 2023
Type: editorial
Abstract: Editorial on the Research Topic Single cell meets metabolism and cancer biologyMetabolism, as an essential biological process in organisms, exerts impacts on almost all physiological processes, like cellular growth and division, and the maintenance of homeostasis.Dysregulation of metabolism is highly related to various modern diseases like diabetes and various cancers.Simultaneously, cancer biology has made significant strides due to the development of a series of omics technologies (e.g., genomics, transcriptomics, and epigenomics).Heterogeneity of cancer cells within and across tumors has been recently recognized as a leading factor in resistance to therapy and disease progression.With the advent and development of single cell sequencing technologies, understanding and characterization of tumor and metabolic heterogeneity in genetic mutation, gene expression, and epigenomic levels has been achieved.Yet in-depth studies at a single cell level to understand the molecular mechanisms and facilitate clinical applications in cancer biology and metabolism remain in their infancy, largely due to the complexity and heterogeneity of the cellular phenotypes involved, which impose formidable barriers to further advancement.To fill this gap, we present this Research Topic to unravel the extent of knowledge improvement on cancer biology and metabolism based on latest development of single cell technologies.Three papers contributed to investigating gliomas from different perspectives.Specifically, Qian et al. characterized ANXA1, a calcium-dependent phospholipid-bind protein, in >1000 Chinese gliomas patients from the molecular and clinical aspects. By leveraging both bulk and single cell RNA sequencing. (RNA-seq) technologies, Qian et al. revealed that ANXA1 highly correlates with immune-related functions and cancer hallmarks.More importantly, ANXA1 is significantly associated with clinical behaviors and patients' survival outcomes, suggesting that it may become an important factor for gliomas diagnosis and treatment.In addition, with the help of single cell technologies, He et al. discovered an important role of SPP1-CD44-medicated crosstalk between cancer cells and macrophages in high-grade glioma.By showing the correlation between high expression levels of SPP1 and CD44 and increasing infiltration of macrophages and poor prognosis of glioma patients, He et al. identified the macrophage-mediated SPP1/CD44 signaling as a critical role of potential target in high-grade glioma treatment.In another study, Xiong et al. found that hypoxia is a poor prognosis marker for primary IDH-wild type glioblastoma (GBM) due to inducing the trend of inhibiting immune cells activity and tumor cells MES-like transformation.By using
Source: Frontiers in Oncology
Authors: Jieqiong Wang, Shibiao Wan
Institution: University of Nebraska Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
Award: G5989231044
OpenAlex ID: W4319737099