Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data
Year: 2023
Type: article
Abstract: PURPOSE: We examined how antecedent sexual health factors affect lower urinary tract symptoms (LUTS) in adolescent women. METHODS: We analyzed 1,941 adolescent women from the Avon Longitudinal Study of Parents and Children at age 19. At ages 15 and 17, participants reported use of oral contraceptives (OCs), history of sexual intercourse, number of sexual partners, and condom use. At age 19, The Bristol Female Lower Urinary Tract Symptoms questionnaire quantified the frequency over the past month: stress incontinence, any incontinence, urgency, sensation of incomplete emptying, bladder pain, and urinary tract infection. Multivariable regression models examined associations between sexual health behaviors reported at ages 15 and 17 and six LUTS reported at age 19, after controlling for covariates. RESULTS: Commonly reported LUTS at age 19 were past-month stress incontinence (26.8%), bladder pain (26.3%), any urine leakage (22.1%), and urinary tract infection (15.4%). OC use by age 17 was associated with urgency (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.19-2.20), incomplete emptying (OR = 1.62, 95% CI = 1.17-2.26), bladder pain (OR = 1.45, 95% CI = 1.15-1.83), and urinary tract infections (OR = 1.68, 95% CI = 1.28-2.21) at age 19 after adjustment for covariates. However, associations were attenuated after adjustment for condom use and number of sexual partners. Sexual intercourse by age 17 was associated with 1.53-2.65 increased odds of LUTs categories except incontinence, with lower confidence interval boundaries > 1.0. Associations were stronger among women with ≥ 3 sexual partners (vs. 0) by age 17. DISCUSSION: We found longitudinally assessed associations between OC use, sexual intercourse, and number of sexual partners during adolescence and LUTS at age 19.
Source: Journal of Adolescent Health
Institutions: Yale University, University of Minnesota, Washington University in St. Louis, University of Alabama at Birmingham, UAB Medicine, Loyola University Chicago, University of California San Diego, University of Michigan, University of Pennsylvania, University of Washington, Boston University
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,270
Funders: Yale University, University of Pennsylvania, University of Minnesota, Washington University in St. Louis, Loyola University Chicago, International Urogynecological Association, Wellcome Trust, Steno Diabetes Center Copenhagen, University of Bristol, Istituto Superiore di Sanità, National Institutes of Health, University of California, San Diego, Medical Research Council, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, Office of Behavioral and Social Sciences Research, Office of Research on Women's Health, National Center for Advancing Translational Sciences, Memphis Research Consortium
Awards: G1044130170, The Truly Healthy Bladder 2: Understanding Normal As A Pathway To Prevention Of Lower Urinary Tract Symptoms In Women, G1128300740, G1245084889, G1344761790, Penn+Plus Clinical Research Center, G1476122343, G1621044260, G1684393010, G1793884970, G1837573645, G1875740499, ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty., Pathways to Lower Urinary Tract Symptoms Prevention in Adolescent and Adult Women., G2056138867, G2280397583, G2373505641, G2408855775, G2522976229, G2602866419, G2759100203, Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Yale Clinical Research Center, G2849166870, G2918647676, G2983253079, G3023266699, G3529030029, G3596103772, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., G3976819198, G3987754321, G4031100373, G4079308200, G4239544819, G4321932201, G4631872170, G4671658612, G4769600488, G4983674564, G5313676757, G5929908560, G593126482, G6538682191, G6570931479, Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site, G6689231961, G6764930405, G7061091857, Bladder health promotion and LUTS prevention inadolescent and adult women across the life course, PLUS Loyola Clinical Center, G7784687571, G7797304306, G792825315, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being., G801210579, G8065198887, G8087389891, G829925373, G8484609832, G8646238196, Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01), G8887566215, G9000062559, G9000202138, G9000252745, Yale Clinical and Translational Science Award
OpenAlex ID: W4320034439