Complication and Failure Rates of Human, Porcine, and Bovine Acellular Dermal Matrix in Prepectoral Breast Reconstruction: A Scoping Review
Year: 2022
Type: article
Abstract: PURPOSE: To determine the rates of overall complications and failure of prepectoral breast reconstruction between various types of human (hADM), bovine (bADM), and porcine (pADM) acellular dermal matrices (ADM). METHODS: Studies examining complications following the use of ADM for prepectoral breast reconstruction were identified using MEDLINE, Embase, the Cochrane Library, LILACS, and the Web of Science from January 2010 to August 2021. Titles and abstracts of 1838 studies were screened, followed by full-text screening of 355 articles. 33 studies were found to meet inclusion criteria. RESULTS: From the thirty-three studies, 6046 prepectoral reconstructions were examined. Implant loss was comparable across the different types of ADM (pADM 4.0%; hADM 4.0%; bADM 3.7%). bADM had the highest rate of capsular contracture (6.1%), infection (9.0%), skin flap necrosis (8.3%), dehiscence (5.4%), and hematoma (6.1%) when compared to both hADM and pADM. hADM had the highest rate of postoperative seroma (5.3%), followed by pADM (4.6%) and bADM (4.5%). CONCLUSION: Among the prepectoral breast reconstruction studies utilizing hADM, pADM, or bADM included in our analysis, complication profiles were similar. bADM had the highest proportion of breast complications in the following categories: capsular contracture, infection rate, skin flap necrosis, dehiscence, and hematoma. Implant loss was comparable across the cohorts. Overall, prepectoral breast reconstruction utilizing ADM leads to relatively low complication rates with the highest rates within the bADM cohort.
Authors: Giovanna Rodosli Pires, Rayaad Hosein, Jayant Agarwal, Whitney Moss, Alvin C. Kwok, Tallie Casucci, Mary McFarland, David Magno-Padron
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,195
OpenAlex ID: W4320064014