Traffic-related air pollution and birth weight: the roles of noise, placental function, green space, physical activity, and socioeconomic status (FRONTIER)
Year: 2022
Type: conference-abstract
Abstract: INTRODUCTION: FRONTIER aimed to provide a robust and comprehensive evaluation of the impact of maternal exposure to traffic-related air pollution (TRAP) on fetal growth. Toward this aim it (1) disentangled the effects of noise as a co-exposure; (2) identified the relevant window(s) of vulnerability for this impact; (3) evaluated its modification by household and neighborhood level socioeconomic status (SES), stress, physical activity, and the timing of conception and delivery in relation to the COVID-19 pandemic lockdown; (4) elucidated the role of placental function as an underlying mechanism; and (5) explored the potential of urban tree canopies and green spaces to mitigate it. METHODS: copper, iron, and zinc in the main microenvironments for pregnant women (home, workplace, and commuting routes). We also assessed maternal exposure to noise by integrating measurements at participants' homes and outdoors using noise monitors with modeled microenvironmental noise levels, data on noise sensitivity, annoyance, and protections against noise. We developed single- and multipollutant models to evaluate the impact of TRAP exposure and inhaled dose on fetal growth while also correcting for the exposure measurement error. We further evaluated the modification of associations by SES, stress (cortisol levels and perceived stress), physical activity (objective and subjective measures), their mitigation by urban greenness and canopy volume, and their mediation by Doppler ultrasound measures of placental function. RESULTS: and fetal growth could be mediated through the impact of these pollutants on placental function (i.e., umbilical artery pulsatility index). CONCLUSIONS: Exposure to TRAP is associated with impaired fetal growth.
Source: ISEE Conference Abstracts
Authors: Payam Dadvand, Maria Dolores Gómez-Roig, Elisa Llurba, Maria Foraster, Gustavo Arévalo, Mariona Bustamante, Xavier Basagaña, Mireia Gascon, Michael Jerrett, Jose Lao, Edurne Mazarico Gallego, Teresa Moreno, Tim Nawrot, Mark J Nieuwenhuijsen, Xavier Querol, Ioar Rivas, Neus Rosell, Joel Schwartz, Cathryn Tonne, Jordi Sunyer
Institutions: Universitat Pompeu Fabra, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universitat de Barcelona, Instituto de Salud Carlos III, Hospital de Sant Pau, University of California, Los Angeles, Institute of Environmental Assessment and Water Research, Hasselt University, Harvard University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4320065896