Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy
Year: 2023
Type: article
Abstract: Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called "microenvironments." Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed.
Source: Stem Cells International
DOI: 10.1155/2023/1655750
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,375
Awards: G1226341917, G1360058561, G1510047722, G156429548, G2395498243, G2718764630, G3460721173, G3514872527, G3586362263, G3658439432, G3723214617, G3841967112, G4503065912, G4543158838, G4887223604, G4970409147, G4983847303, G5178454006, G584019000, G5861842840, G6062315302, G6123428706, G6154547656, G6205584820, G651080643, G6609502102, G6693039447, G6882706751, G6904853188, G6957911196, G7201286585, G7250188592, G7363618224, G7398907697, G7439477012, lncRNA NP-FoxA2通路在仿生II型胶原/硫酸软骨素支架诱导脂肪干细胞成髓核细胞分化中的作用及机制研究, G7518445014, G7812081625, G7853895445, G7874357266, G7932433723, G797786838, G8680744588, G8746316933
OpenAlex ID: W4320485487