Integrative analyses reveal prognostic and immunogenic characteristics of m7G methylation regulators in patients with glioma.
Year: 2023
Type: article
Abstract: OBJECTIVES: The expression profiles, biological mechanisms, and clinical relevance of m7G regulators in glioma were studied in this research. METHODS: Based on the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets, glioma patients, can be categorized into three groups according to 29 m7G regulators, and different subtypes of glioma show different immune cell infiltration characteristics, function enrichment, and clinical prognosis. Three gene clusters were confirmed by utilizing the differentially expressed genes (DEGs) across the three m7G clusters. RESULTS: progression of glioma cells by regulating PD-L1 expression through p53 signaling pathway-related inactivation. CONCLUSIONS: experiment suggested the potential biological mechanisms of immune regulation, with m7G regulators affecting glioma progression by modulating immune responses. The present research provides a better understanding of how m7G regulators function in glioma progression as well as the impact on clinical outcomes, which can provide new insights that might be beneficial for precision therapy of glioma.
Source: PubMed Central
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4320506984