Work

Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis.

Year: 2023

Type: article

Abstract: and in clinical trials against a variety of solid malignancies.

Source: PubMed Central

Authors: Francesca R Di Cristofano, Mara W Fong, Kelsey E Huntington, Benedito A Carneiro, Lanlan Zhou, Wafik S El-Deiry

Institutions: Brown University, Lifespan, Rhode Island Hospital

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Brown University, National Institutes of Health, National Cancer Institute

Award: ONC201/TIC10 Anti-tumor Effect Through Regulation of the TRAIL pathway

OpenAlex ID: W4320507006

FWCI: 0.756

Cites: 43

Cited by: 10

Related to: 10