KCTD10 functions as a tumor suppressor in hepatocellular carcinoma by triggering the Notch signaling pathway.
Year: 2023
Type: article
Abstract: OBJECTIVE: Our previous study found KCTD10 negatively regulates Notch signaling, but whether KCTD10 regulates human hepatocellular carcinoma (HCC) carcinogenicity was uncertain. METHODS: tumorigenicity, cancer stem cell (CSC) biomarkers and Notch signaling variation. RESULTS: cell population. Further molecular studies showed that the transmembrane/intracellular region (NTM) of Notch1 decreased when KCTD10 was knocked down in HCC cell lines, and that the balance between P53 and Notch activity was regulated. CONCLUSIONS: The results demonstrated that KCTD10 can act as a tumor suppressor in HCC cells through Notch signaling.
Source: PubMed Central
Institution: Hunan Normal University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4320507816