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HD-tDCS in acute and long-term COVID-19

Year: 2023
Type: article
Abstract: funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.To better understand the physiology of the indirect effects of tDCS, we investigated the raphe activity in response to acute and chronic prefrontal-tDCS, in particular by analysing serotonin (5-HT) neural activity by singleunit in-vivo electrophysiology and HPLC.Indeed, one of the main neurotransmitters involved in the pathophysiology and psychopharmacology of depression is 5-HT, released by neurons of the dorsal raphe nuclei.We observed different spontaneous firing outcomes after acute and chronic tDCS, with some effects lasting up to one month.Additionally, in the motor cortex, we observed that the combination of tDCS and physical activity results in a boosting effect of neural plasticity in both hemispheres.Altogether, these data indicate a strong functional influence of tDCS on cortical connectivity, and not only in the directly stimulated region.
DOI: 10.1016/j.brs.2023.01.230
Authors: Suellen Andrade, Eduardo França, Cecilia Silvestre, Kelly Santana, Vanessa Cintra, Joao Sato, Egas Capareli-Dáquer, Benjamin Hampstead, Antonio Teixeira, Marom Bikson
Institutions: Universidade Federal da Paraíba, Governo do Estado de Paraíba, Universidade Federal do ABC, Universidade do Estado do Rio de Janeiro, University of Michigan, Michigan Medicine, City College of New York
Language: English
Subfield: Neurology
Open Access status: gold
Estimated APC paid: $3,830
OpenAlex ID: W4320907263
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