Work

The covalent nucleotide modifications within plant mRNAs: What we know, how we find them, and what should be done in the future

Year: 2023

Type: article

Abstract: Although covalent nucleotide modifications were first identified on the bases of transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), a number of these epitranscriptome marks have also been found to occur on the bases of messenger RNAs (mRNAs). These covalent mRNA features have been demonstrated to have various and significant effects on the processing (e.g. splicing, polyadenylation, etc.) and functionality (e.g. translation, transport, etc.) of these protein-encoding molecules. Here, we focus our attention on the current understanding of the collection of covalent nucleotide modifications known to occur on mRNAs in plants, how they are detected and studied, and the most outstanding future questions of each of these important epitranscriptomic regulatory signals.

Source: The Plant Cell

DOI: 10.1093/plcell/koad044

Authors: Wil Prall, Diep R Ganguly, Brian D Gregory

Institution: University of Pennsylvania

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, Division of Integrative Organismal Systems

Awards: G4052643120, RESEARCH-PGR: Elucidating the role of epitranscriptome on adaptation to abiotic stresses in cereals, TRTech-PGR: Identification and characterization of stress-responsive and evolutionary conserved epitranscriptomic modification sites in plant transcriptomes., G5389862754, G744565469