Year: 2023
Type: review
Abstract: Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
Source: Frontiers in Pharmacology
Authors: Di Ye, Yinghui Liu, Heng Pan, Yongqi Feng, Xiyi Lu, Liren Gan, Jun Wan, Jing Ye
Institutions: Wuhan University, Renmin Hospital of Wuhan University
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
Award: G8094813573
OpenAlex ID: W4321597359