Migraine and restless legs syndrome in women
Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Few clinic-based studies report an association between migraine and restless legs syndrome (RLS); however, population-based data are unavailable. METHODS: Cohort study among 31,370 women participating in the Women's Health Study. We had detailed self-reported information on migraine, including aura status, and RLS. RLS was ascertained at the 9-year follow-up. We calculated odds ratios (OR) and 95% confidence intervals (CI) for the association between migraine and RLS. We investigated any indication of migraine until RLS ascertainment as well as migraine with and without aura at baseline, prior migraine before baseline, and new reports of migraine during follow-up. RESULTS: At baseline or during follow-up 6857 (21.9%) women reported any migraine. These women had an increased risk for RLS (multivariable-adjusted OR = 1.22; 95%CI 1.13-1.32). Further analyses indicated a similar association for migraine with aura (multivariable-adjusted OR = 1.27; 95%CI 1.10-1.48) and migraine without aura (multivariable-adjusted OR = 1.24; 95%CI 1.09-1.40) as well as for new reports of migraine during follow-up (multivariable-adjusted OR = 1.30; 95%CI 1.10-1.54). Prior migraine did not appear to be associated with RLS. CONCLUSIONS: Our data suggest an association between migraine and RLS at the population level. The association is similar for migraine with and without aura and for new reports of migraine during follow-up.
Source: Cephalalgia
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Women's Health Study: Continued Follow-Up, G1528515809, G229684361, G2716548166, G286033693, The Women's Health Study: Addition of New Data to Maximize its Research Impact, G6008908520, G6084477511, Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Events, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, Women's Health Study: Continued Follow-up
OpenAlex ID: W4322388199