Research Opportunities in Stroke Prevention for Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop
Year: 2023
Type: review
Abstract: Atrial fibrillation (AF) is one of the strongest risk factors for ischemic stroke, which is a leading cause of disability and death. Given the aging population, increasing prevalence of AF risk factors, and improved survival in those with cardiovascular disease, the number of individuals affected by AF will continue increasing over time. While multiple proven stroke prevention therapies exist, important questions remain about the optimal approach to stroke prevention at the population and individual patient levels. Our report summarizes the National Heart, Lung, and Blood Institute virtual workshop focused on identifying key research opportunities related to stroke prevention in AF. The workshop reviewed major knowledge gaps and identified targeted research opportunities to advance stroke prevention in AF in the following areas: (1) improving risk stratification tools for stroke and intracranial hemorrhage; (2) addressing challenges with oral anticoagulants; and (3) delineating the optimal roles of percutaneous left atrial appendage occlusion and surgical left atrial appendage closure/excision. This report aims to promote innovative, impactful research that will lead to more personalized, effective use of stroke prevention strategies in people with AF.
Source: Stroke
Authors: Alan S. Go, Sana M. Al-Khatib, Patrice Desvigne-Nickens, Nisha Bansal, Cheryl D. Bushnell, Margaret C. Fang, James V. Freeman, Brian F. Gage, Thorsten Hanke, Elaine M. Hylek, Renato D. Lopes, Peter A. Noseworthy, Vivek Y. Reddy, Daniel E. Singer, Kevin L. Thomas, Mellanie True Hills, Mintu P. Turakhia, Susan J. Zieman, Lawton S. Cooper, Emelia J. Benjamin
Institutions: Kaiser Permanente, University of California, San Francisco, Kaiser Permanente Bernard J. Tyson School of Medicine, Kaiser Permanente Northern California, Duke University, Duke Clinical Research Institute, National Institutes of Health, National Heart, Lung, and Blood Institute, University of Washington, Wake Forest University Health Sciences, Wake Forest University, Yale University, Yale New Haven Health System, Washington University in St. Louis, Asklepios Klinikum Harburg, Boston University, Mayo Clinic, Icahn School of Medicine at Mount Sinai, Harvard University, Massachusetts General Hospital, StopAfib.org, VA Palo Alto Health Care System, Stanford University, National Institute on Aging, Boston Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, U.S. Food and Drug Administration, Agency for Healthcare Research and Quality, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: FHS-NEXT - Framingham Novel EXam using Technology, Heart failure and atrial arrhythmias in CKD, The Atrial Fibrillation-Factor Identification to Risk Modification Study in CKD/ESRD, Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF), G225606699, AFGen Consortium: Atrial Fibrillation Genomics to Functional Analyses, Shared decision making for stroke prevention in atrial fibrillation (SDM4Afib), Direct-Acting Oral Anticoagulants: Anticoagulant Activity in Understudied Older NVAF Patients, Optimizing stroke prevention for older adults with atrial fibrillation: Towards rigorous evaluation and judicious application of a new device, Optimizing Atrial Fibrillation Management in CKD, Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF), G7395343366, Use and outcomes of anticoagulants for the treatment and prevention of thrombosis among hospitalized patients, Pain in community-based older African American Adults: The Jackson Heart Study, IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL, PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization, CAPSITE: Community Assessment of Pain and Sensitization in the Elderly, Yale Clinical and Translational Science Award
OpenAlex ID: W4322490506