Year: 2023
Type: editorial
Abstract: R ecent studies have provided mechanistic and conceptual connections among the functions of pioneer transcription factors, ATP-dependent chromatin remodelers, molecular motors, and genome structure.We previously provided our perspective on key points of epigenetic interactivity at different scales of genome organization, with a focus on rapid kinetically controlled experiments.1 Now, we are especially interested in newly published studies that address the spectrum between canonical transcription factors (TFs), which bind only accessible chromatin regions, and pioneering transcription factors (PFs), which can invade closed chromatin to destabilize nucleosomes.There is increasing evidence that pioneer transcription factors influence a variety of developmental and oncogenic contexts, across cell state and even across species.We describe a few representative advances which connect transcription and pioneer factors to other components of epigenome regulation.
Source: Biochemistry
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4322492406