Work

Disrupting the Mood and Obesity Cycle: The Potential Role of Metformin

Year: 2023

Type: article

Abstract: Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised metabolic health and psychological functioning worsen clinical outcomes, diminish quality of life, and contribute to comorbid conditions. As a medication with both insulin-sensitizing and anti-inflammatory effects, metformin affords the exciting opportunity to abrogate the bidirectional relationship between poor metabolic health and psychological function. In the current paper, we review the literature linking metformin to mood and cognitive function, examine potential underlying mechanisms, and suggest new directions for investigating the role of metformin in increasing adherence to health behavior recommendations.

Source: Obesities

DOI: 10.3390/obesities3010006

Authors: Stacey N. Doan, Sunita K. Patel, Bin Xie, Rebecca A. Nelson, Lisa D. Yee

Institutions: Claremont McKenna College, City Of Hope National Medical Center, City of Hope, Claremont Graduate University

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,112