Year: 2023
Type: article
Abstract: We explain the principles of gene expression pattern stabilization in systems of interacting, diffusible morphogens, with dynamically established source regions. Using a reaction-diffusion model with a step-function production term, we identify the phase transition between low-precision indeterminate patterning and the phase in which a traveling, well-defined contact zone between two domains is formed. Our model analytically explains single- and two-gene domain dynamics and provides pattern stability conditions for all possible two-gene regulatory network motifs.
Source: Physical Review Letters
Authors: M. Majka, R. D. J. G. Ho, M. Zagorski
Institution: Jagiellonian University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: G3084147811
OpenAlex ID: W4322732852