Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States
Year: 2023
Type: article
Study design: Observational Study
Abstract: Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.
Source: Frontiers in Medicine
Institutions: National Cancer Institute, Division of Cancer Epidemiology and Genetics, Stanford Medicine, Stanford University, University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Montefiore Health System, University of Miami Health System, John H. Stroger, Jr. Hospital of Cook County, Hektoen Institute, Cook County Health and Hospitals System, Georgetown University Medical Center, University of California, San Francisco, University of Alabama at Birmingham, UAB Medicine, Emory University, Grady Health System, Johns Hopkins University, University at Albany, State University of New York
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Funders: Johns Hopkins University, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Center for AIDS Research, University of Washington, University of California, San Francisco, Center for AIDS Research, University of Alabama at Birmingham, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities, Center for AIDS Research, University of North Carolina at Chapel Hill, Clinical and Translational Science Institute, University of California, Los Angeles
Awards: G1034546755, G1296759572, G1913134163, G2008237588, G2483435703, G311558797, G3869857964, G4044828089, Clinical and Translational Science Institute, G5900455136, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G6745172908, G6990385686, G7178514535, G775892330, G7807729167, Johns Hopkins Institute for Clinical and Translational Research, G9000080293, G9000082816, The Johns Hopkins Center for AIDS Research (JHU CFAR), Center for AIDS Research at Emory University, The University of North Carolina Center for AIDS Research, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Miami Center for AIDS Research, UCLA Clinical and Translational Science Institute, UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4322772769