Work

Remdesivir-Induced Bradycardia

Year: 2023

Type: article

Abstract: Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved to improve recovery time; however, remdesivir also can induce significant cytotoxic effects on cardiac myocytes. In this narrative review, we discuss the pathophysiological mechanism of remdesivir-induced bradycardia and diagnostic and management strategies for these patients. We conclude that further research is necessary to understand better the mechanism of bradycardia in coronavirus disease 2019 patients with or without cardiovascular disorder treated with remdesivir.

Source: Southern Medical Journal

DOI: 10.14423/smj.0000000000001519

Authors: Sai Gautham Kanagala, Hardeep Dholiya, Poonam Jhajj, Meet A. Patel, Vasu Gupta, Sachin Gupta, Shiau-ing Wu, Rohit Jain

Institutions: Osmania Medical College, Tianjin Medical University, Avalon University School of Medicine, Dayanand Medical College & Hospital, Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4323035004

FWCI: 2.068

Cites: 13

Cited by: 10

Related to: 10