Work

Synthetic biology tools for engineering Corynebacterium glutamicum

Year: 2023

Type: review

Abstract: Corynebacterium glutamicum is a promising organism for the industrial production of amino acids, fuels, and various value-added chemicals. From the whole genome sequence release, C. glutamicum has been valuable in the field of industrial microbiology and biotechnology. Continuous discovery of genetic manipulations and regulation mechanisms has developed C. glutamicum as a synthetic biology platform chassis. This review summarized diverse genomic manipulation technologies and gene expression tools for static, dynamic, and multiplex control at transcription and translation levels. Moreover, we discussed the current challenges and applicable tools to C. glutamicum for future advancements.

Source: Computational and Structural Biotechnology Journal

DOI: 10.1016/j.csbj.2023.03.004

Authors: Gi Yeon Kim, Jinyoung Kim, Geunyung Park, Hyeon Jin Kim, Jina Yang, Sang Woo Seo

Institutions: Seoul National University, Jeju National University, Institute of Engineering Research

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,230

Funders: National Research Foundation, Ministry of Oceans and Fisheries, Korea Institute of Marine Science and Technology promotion, Ministry of Science and ICT, South Korea