Year: 2023
Type: article
Study design: Observational Study
Abstract: AIMS: Ketone bodies (KB) are an important alternative metabolic fuel source for the myocardium. Experimental and human investigations suggest that KB may have protective effects in patients with heart failure. This study aimed to examine the association between KB and cardiovascular outcomes and mortality in an ethnically diverse population free from cardiovascular disease (CVD). METHODS AND RESULTS: This analysis included 6796 participants (mean age 62 ± 10 years, 53% women) from the Multi-Ethnic Study of Atherosclerosis. Total KB was measured by nuclear magnetic resonance spectroscopy. Multivariable-adjusted Cox proportional hazard models were used to examine the association of total KB with cardiovascular outcomes. At a mean follow-up of 13.6 years, after adjusting for traditional CVD risk factors, increasing total KB was associated with a higher rate of hard CVD, defined as a composite of myocardial infarction, resuscitated cardiac arrest, stroke, and cardiovascular death, and all CVD (additionally included adjudicated angina) [hazard ratio, HR (95% confidence interval, CI): 1.54 (1.12-2.12) and 1.37 (1.04-1.80) per 10-fold increase in total KB, respectively]. Participants also experienced an 87% (95% CI: 1.17-2.97) increased rate of CVD mortality and an 81% (1.45-2.23) increased rate of all-cause mortality per 10-fold increase in total KB. Moreover, a higher rate of incident heart failure was observed with increasing total KB [1.68 (1.07-2.65), per 10-fold increase in total KB]. CONCLUSION: The study found that elevated endogenous KB in a healthy community-based population is associated with a higher rate of CVD and mortality. Ketone bodies could serve as a potential biomarker for cardiovascular risk assessment.
Source: European Heart Journal
Institutions: Tel Aviv Sourasky Medical Center, Atrium Health Wake Forest Baptist, Wake Forest University Health Sciences, Wake Forest University, Geisinger Medical Center, Geisinger Health System, University of Chicago, Stanford Medicine, Stanford University, Inova Health System, Johns Hopkins University, The University of Texas Southwestern Medical Center, Brigham and Women's Hospital, Harvard University
Language: English
Topic: Diet and metabolism studies
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1261793039, MESA, G1276754516, G1294553593, G1409423729, G1539384734, G1640378483, G1686417863, G1803853571, Wake Forest Clinical and Translational Science Award, G1983464145, G2095942735, G2144938473, G22458031, G2248434558, G2262782284, MESA, G2580996367, MESA, G2837638605, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3482531243, G3568487487, G3570589137, G3595232572, G3647016462, G3687594596, MESA, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4512137732, G4563812999, G4590187187, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G4986157935, G5075046117, G5108002584, G514410172, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5653954166, G5787256936, G6095866717, G6359107525, Institute for Clinical and Translational Research, MESA, G6514094751, G66341962, G6856766826, G7166352866, MESA, G7455404317, G78770644, Clinical and Translational Science Award, G8145863542, G8761005068, G991334795
OpenAlex ID: W4323351983