Year: 2022
Type: article
Abstract: Despite many studies of potential delirium biomarkers, delirium pathophysiology remains unclear. Evidence shows that the quality of reporting delirium biomarker studies is sub-optimal. Better reporting of delirium biomarker studies is needed to understand delirium pathophysiology better. To improve robustness, transparency and uniformity of delirium biomarker study reports, the REDEEMS (Reporting Essentials for DElirium bioMarker Studies) guideline was developed by an international group of delirium researchers through a three-stage process, including a systematic review, a three-round Delphi study, and a follow-up consensus meeting. This process resulted in a 9-item guideline to inform delirium fluid biomarker studies. To enhance implementation of the REDEEMS guideline, this Explanation and Elaboration paper provides a detailed explanation of each item. We anticipate that the REDEEMS guideline will help to accelerate our understanding of delirium pathophysiology by improving the reporting of delirium biomarker research and, consequently the capacity to synthesise results across studies.
Source: Delirium
DOI: 10.56392/001c.57389
Institutions: University of Technology Sydney, The Kids Research Institute Australia, The University of Notre Dame Australia, UNSW Sydney, Prince of Wales Hospital, Sligo University Hospital, Oslo University Hospital, Trinity College Dublin, Johns Hopkins University, Johns Hopkins Medicine, Indiana University School of Medicine, Regenstrief Institute, Mayo Clinic, The University of Sydney, Royal Prince Alfred Hospital, Umeå University, University of Pittsburgh, University of Basel, Beth Israel Deaconess Medical Center, Harvard University, Ingham Institute
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4323520286