Multiomics profiling of the impact of an angiotensin (1–7)-expressing probiotic combined with exercise training in aged male rats
Year: 2023
Type: article
Abstract: This manuscript uses a multiomics approach (i.e., microbiome, metabolomics, and transcriptomics) to explore the underlying mechanisms driven by a genetically modified probiotic (GMP) designed to express angiotensin (1-7) combined with moderate exercise training in an aged male rat model. After 12 wk of intervention, our findings suggest that our GMP enhanced gut microbial diversity while exercise training altered the transcriptional response in relevant neuroremodeling genes, inflammation, and circadian rhythm signaling pathways in an aging animal model.
Source: Journal of Applied Physiology
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: hybrid
Funders: U.S. Department of Veterans Affairs, University of Alabama at Birmingham, Universidade do Porto, National Institutes of Health, Fundação para a Ciência e a Tecnologia, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Nathan Shock Center, University of Alabama at Birmingham
Awards: G1233089687, G1889192661, G2072897566, G3216481712, G3252227514, G4022413448, G568042745, ACE2 as a novel therapeutic to preserve physical function in late life, G6786127310, G6831145233, Pain, Distress and Mammography Use in Breast Cancer Patients, Mechanisms of Hypertension and Cardiovascular Diseases, Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.
OpenAlex ID: W4323652387